解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Bile acid conjugates are found in human breast cyst fluid in average concentrations about 50-fold greater than those in blood. Because epidemiologic studies have linked colon and breast cancer and aberrant bile acid profiles are associated with colon cancer risk, we decided to study the influence of bile acid conjugat...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(97)00050-0
更新日期:1997-10-01 00:00:00
abstract::To gain further insight into the mechanism for inactivation of aromatase by androst-5-ene-7,17-dione (1) and its 19-nor analog 4, 10 beta-oxygenated steroids 5 and 6, delta 1(10)-steroid 7, and 19-oxo-5 beta,6 beta-epoxy compound 8 were synthesized and tested for their ability to inhibit aromatase in human placental m...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(97)00002-0
更新日期:1997-07-01 00:00:00
abstract::A facile method for the synthesis of a series of new steroidal 3-thioxamides from the 3-oxo compound, variously substituted at the 17 position, is described. The "one pot" reaction, using Lawesson's reagent (4-methoxyphenylthionophosphine sulphide dimer) in dichloromethane solution, gives the desired compounds with a ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(97)00003-2
更新日期:1997-06-01 00:00:00
abstract::The high concentrations of dehydroepiandrosterone sulfate and pregnenolone sulfate in the mammalian brain, despite the blood-brain barrier's impermeability to these compounds, and the apparent independence of these concentrations from those in plasma prompted us to investigate whether enzymatic sulfation of dehydroepi...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(97)00013-5
更新日期:1997-05-01 00:00:00
abstract::Carbenoxolone potentiates the mineralocorticoid activity of endogenous glucocorticoid hormones by inhibiting the enzyme 11 beta-hydroxysteroid dehydrogenase, which converts cortisol and corticosterone to inactive 11-oxo-derivatives. We addressed the question of whether glucocorticoid activity is also affected by carbe...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(96)00252-8
更新日期:1997-04-01 00:00:00
abstract::11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), the enzyme that catalyzes the conversion of biologically active glucocorticoids to their inactive metabolites, was shown to be located exclusively in Leydig cells of the rat testis, and its appearance was associated with the developmental rise in testosterone. Thus, ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(96)00225-5
更新日期:1997-03-01 00:00:00
abstract::We report the synthesis of 10 novel steroids obtained from 3 beta, 15 beta-diacetoxy-17 alpha-hydroxy-5-pregnen-20-one (1c) as intermediates in the synthesis of 15 beta-acetoxy-20,20-ethylenedioxy-17 alpha-hydroxy-4-pregnen-3-one (6a) and its tritiated tracer 15 beta-acetoxy-20,20-ethylenedioxy-17 alpha-hydroxy-1,2,6,...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(96)00204-8
更新日期:1997-02-01 00:00:00
abstract::17 beta-Hydroxysteroid dehydrogenase (17 beta-HSD) controls the last step in the formation of all androgens and all estrogens. This crucial role of 17 beta-HSD is performed by at least five 17 beta-HSD isoenzymes having individual cell-specific expression, substrate specificity, regulation mechanisms, and reductive or...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(96)00174-2
更新日期:1997-01-01 00:00:00
abstract::The syndrome of apparent mineralocorticoid excess (AME) is an inherited form of hypertension in which 11 beta-hydroxysteroid dehydrogenase (11-HSD) is defective. This enzyme converts cortisol to its inactive metabolite, cortisone. The deficiency allows mineralocorticoid receptors to be occupied by cortisol, because th...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/s0039-128x(96)00164-x
更新日期:1997-01-01 00:00:00
abstract::Steroidogenesis begins with the metabolism of cholesterol to pregnenolone by the inner mitochondrial membrane cytochrome P450 side-chain cleavage (P450scc) enzyme. The rate of steroid formation, however, depends on the rate of cholesterol transport from intracellular stores to the inner mitochondrial membrane and load...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/s0039-128x(96)00154-7
更新日期:1997-01-01 00:00:00
abstract::Estrogen sulfamates are promising hormones by oral administration. Therefore, generally applicable and convenient methods for the multigram synthesis of these derivatives are desirable. Numerous estra-1,3,5(10)-trienes derived from estrone, estradiol. 14 alpha,15 alpha-methylenestradiol, ethinylestradiol, and estriol ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(96)00200-0
更新日期:1996-12-01 00:00:00
abstract::This study represents a continuing effort to find a new biomarker for the diagnosis and management of prostatic cancer. Polyclonal antibodies were prepared to a peptide (CAKP) representing amino acids 28 to 43 of the 5 alpha-reductase type 2 isozyme. Using immunoaffinity-purified antibodies, the sera of 62 patients we...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(96)00184-5
更新日期:1996-11-01 00:00:00
abstract::The synthesis of seco-D and D-homo digitalis derivatives, from the carda-14,20(22)-dienolide 1, is described. Selective ozonolysis gave the seco-D 14-ketoaldehyde 2a. Modification of the two carbonyl groups and of the alpha, beta-unsaturated lactone ring of the seco-D 14-ketoaldehyde 2a allowed preparation of derivati...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(96)00117-1
更新日期:1996-10-01 00:00:00
abstract::The synthesis of (22E,24R)-5 alpha-ergosta-2,22-dien-6-one (2), a key intermediate to the preparation of 24-epibrassinolide (1), was achieved through the 3,6-diketone 8 in a 40% overall yield in five steps starting from ergosterol (3). ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(96)00087-6
更新日期:1996-09-01 00:00:00
abstract::Through its collaboration with the ETH in Zurich (Ruzicka's group) and later on with the University of Basel (Reichstein's group). Ciba became involved very early in steroid chemistry. The main task of the chemists consisted at that time of the synthesis of natural hormones and their derivatives. Cholesterol served fo...
journal_title:Steroids
pub_type: 历史文章,杂志文章
doi:10.1016/0039-128x(96)00040-2
更新日期:1996-08-01 00:00:00
abstract::Androgen-binding protein/sex hormone-binding globulin (ABP/SHBG) is an extracellular carrier protein that binds androgens and estrogens with high affinity. In the adult, ABP/SHBG is thought to function in the male reproductive system and the general circulation in both sexes to modulate the actions of sex steroids. Th...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(96)00049-9
更新日期:1996-07-01 00:00:00
abstract::Because diffusion of testosterone (T) into the salivary gland is thought to be largely limited to the free, biologically active fraction, salivary testosterone is expected to provide a better measure of testosterone bioavailability in the body than is plasma testosterone. Matched saliva and blood spot samples were col...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(96)00043-8
更新日期:1996-06-01 00:00:00
abstract::The present study was undertaken to examine the mechanism whereby beta-lipotropin stimulates adrenal steroidogenesis. In guinea pig adrenal cells, beta-lipotropin (10(-8) M) increased basal steroid production 6-, 4-, and 5-fold for cortisol, androstenedione, and dehydroepiandrosterone (DHEA), respectively, whereas the...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(96)00002-5
更新日期:1996-05-01 00:00:00
abstract::In each menstrual cycle only very few follicles in the mammalian ovary undergo maturation and ovulation while most of the follicles degenerate in the process of atresia. Moreover, in the absence of pregnancy, the newly formed corpora lutea will degenerate and disappear in the process of luteolysis. Recent studies sugg...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/0039-128x(96)00031-1
更新日期:1996-04-01 00:00:00
abstract::The 11 beta-hydroxysteroid dehydrogenase type II enzyme (11 beta HSD2) converts cortisol to cortisone, allowing the non-selective mineralocorticoid receptor to bind aldosterone. When the activity of this enzyme is compromised, as occurs in licorice intoxication or in the congenital syndrome of apparent mineralocortico...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(96)00013-x
更新日期:1996-04-01 00:00:00
abstract::The use of the synthetic progestin medroxyprogesterone acetate (MPA) for estrus prevention in the dog can result in overproduction of growth hormone, suppression of plasma glucocorticoid levels, and the induction of mammary tumors. Proligestone (PROL) was claimed to be devoid of these unwanted side effects. In the pre...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(95)00216-d
更新日期:1996-03-01 00:00:00
abstract::We report the synthesis of 3 beta,15 beta,17 alpha-trihydroxy-5-pregnen-20- one (1) from 3 beta,15 beta-dihydroxy-5,16-pregnadien-20-one (11) in 7 steps using boronate derivatives as a means of protecting the 17,20-glycol side-chain of steroid intermediates. 16 alpha,17 alpha-Epoxy-3 beta,15 beta-dihydroxy-5- pregnen-...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(95)00169-q
更新日期:1996-01-01 00:00:00
abstract::The palladium-catalyzed coupling of various 17-iodo-delta 16 steroids (17-iodo-androst-16-ene, 17-iodo-4-methyl-4-aza-androst-16-en-3-one, and 17-iodo-4-aza-androst-16-en-3-one) with dialkyl phosphites (dimethyl phosphite, diethyl phosphite, and diisopropyl phosphite) was examined in detail. The only successful condit...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(95)00121-6
更新日期:1995-12-01 00:00:00
abstract::During our studies of the hepatic androgen receptor in cynomolgus monkeys, tritiated mibolerone +/- a 200-fold excess of unlabeled mibolerone has been used to determine specific binding in cytosol. During time-course studies, high-capacity, unsaturable binding of [3H]mibolerone was noted after short-term incubations (...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(95)00116-8
更新日期:1995-11-01 00:00:00
abstract::The determination of the glucurono-conjugated position in three bile alcohol glucuronides secreted in bile of a patient with cerebrotendinous xanthomatosis was carried out by a nuclear magnetic resonance study. The bile sample was extracted with ethanol and chromatographed on an ion-exchange column, a reverse-phase pa...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(95)00095-8
更新日期:1995-10-01 00:00:00
abstract::A radioimmunoassay of three deoxycorticoids, namely 11 beta,17 alpha-dihydroxy-4-pregnene-3,20-dione (21-deoxycortisol), 17 alpha,21-dihydroxy-4-pregnene-3,20-dione (11-deoxycortisol), and 21-hydroxy-4-pregnene-3,20-dione (11-deoxycorticosterone) which are important for differential diagnosis of congenital adrenal dis...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(95)00060-4
更新日期:1995-09-01 00:00:00
abstract::We have investigated the metabolism of deoxycorticosterone in A6 cells, a continuous cell line derived from the kidney of Xenopus laevis. A6 cells at confluence were incubated with serum-free culture media containing 2.5 microM [3H] deoxycorticosterone. When radioactive compounds in incubation media were separated by ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(95)00038-r
更新日期:1995-07-01 00:00:00
abstract::Synthesis of 3 beta,17 beta-dihydroxy-7 alpha/7 beta-(4-hydroxyphenyl)-androst-5-ene 3,17-diacetate (4 and 5, R = H) and 3 beta,17 beta-dihydroxy-7 alpha/7 beta-(4-methoxyphenyl)-androst-5-ene 3,17-diacetate (4 and 5, R = Me) have been carried out by Friedel-Crafts reaction on 3 beta,7,17 beta-trihydroxy-androst-5-ene...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(95)00007-d
更新日期:1995-06-01 00:00:00
abstract::Nucleocytoplasmic shuttling of glucocorticoid receptors (GRs) is disrupted in v-mos-transformed cells leading to the redistribution of hormone-bound receptors from the nuclear to cytoplasmic compartments. We show here that GRs from v-mos-transformed cells are hyperphosphorylated on a specific peptide and maintain horm...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(94)00068-n
更新日期:1995-05-01 00:00:00
abstract::The 21-hydroxy analogues of 11,19-oxidoprogesterone and 6,19-oxidoprogesterone have been synthesized from readily available materials. Hydroxylation at C-21 was effected with iodosobenzene (from phenyliodosodiacetate and methanolic potassium hydroxide) on a 20-ketopregnane. For the 11,19-oxido derivative, the hydroxyl...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(94)00052-e
更新日期:1995-03-01 00:00:00
abstract::The purpose of this study was to investigate the influence of plasma steroid-binding proteins on androgen metabolism in intact leukocytes prepared from normal male and female blood samples. Leukocyte preparations were incubated for 24 h at 37 degrees C with either labeled or unlabeled testosterone (T), 5 alpha-dihydro...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(94)00042-b
更新日期:1995-02-01 00:00:00
abstract::Glucocorticoid receptor binding was compared in liver cytosol preparations from spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats using homologous displacement of [3H]dexamethasone. At 5 degrees C, there was no difference in receptor binding affinity or concentration between strains for dexamethasone, ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(94)00011-z
更新日期:1995-01-01 00:00:00
abstract::In comparison with the glucocorticoids cortisol and corticosterone, the mineralocorticoid aldosterone is a minority hormone of the mammalian adrenal cortex, and its proper function is dependent upon protective physiological mechanisms. These include a particular site of aldosterone synthesis in zona glomerulosa cells ...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/0039-128x(94)00021-4
更新日期:1995-01-01 00:00:00
abstract::11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), by converting cortisol and corticosterone to hormonally inactive cortisone and 11-dehydrocorticosterone, respectively, is an important pre-receptor signaling pathway for the renal mineralocorticoid receptor (MR). This receptor has an equal affinity for the glucocorti...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(94)00024-7
更新日期:1995-01-01 00:00:00
abstract::Nuclear membrane bound testosterone 5 alpha-reductase solubilized in active form from human prostatic tissue by 0.5% n-octyl beta-D-glucopyranoside was purified by a four-step chromatographic procedure including DEAE-Trisacryl ion exchange, hydroxylapatite adsorption, testosterone-Sepharose affinity and Sepharose 4B g...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(94)90103-1
更新日期:1994-12-01 00:00:00
abstract::Finasteride is a specific 5 alpha-reductase inhibitor that has been shown to reduce the size of human benign prostatic hyperplasia (BPH) by inhibiting the intraprostatic conversion of testosterone to 5 alpha-dihydrotestosterone. The aim of the present in vitro study was to describe in more detail the inhibitory effect...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(94)90016-7
更新日期:1994-11-01 00:00:00
abstract::The biotransformation of a series of delta 4-3-ketosteroids by the fungus Penicillium decumbens ATCC 10436 has been investigated. Conversion to the 5 alpha-dihydrosteroid was observed for several substrates of the androstene and pregnene series: the reaction is tolerant of non-polar substituents (Cl and CH3) at C-4 of...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(94)90020-5
更新日期:1994-11-01 00:00:00
abstract::The ALVA-41 cell line was derived from a bony metastasis from a human prostatic carcinoma. The line has a number of distinct, advantageous properties that should make it useful as a tool for the study of prostate cancer. It grows rapidly and is easy to work with. It has receptors for androgens and glucocorticoids but ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(94)90052-3
更新日期:1994-10-01 00:00:00
abstract::To investigate the effects of conjugated bile acid on bacterial growth and cholylglycine hydrolase activity, Clostridium perfringens from human feces was exposed to varying concentrations of taurine- or glycine-conjugated chenodeoxycholic acid. Extracellular enzyme activity was determined by deconjugation of radiolabe...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(94)90062-0
更新日期:1994-08-01 00:00:00
abstract::3 alpha-Hydroxysteroid dehydrogenase (3 alpha HSD) is one of the main enzymes involved in the metabolism of the active androgen, dihydrotestosterone (DHT). 3 alpha HSD catalyzes the reversible reduction of DHT to 5 alpha-androstane-3 alpha, 17 beta-diol (3 alpha DIOL). The equilibrium of 3 alpha HSD reductive and oxid...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(94)90110-4
更新日期:1994-04-01 00:00:00